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The word 'Vicissitude' is a noun and can be pronounced as
'vuh-si-suh-chood' (/vi´sisi¸tju:d/).
The meaning of the word is 'a change of circumstances or fortune, typically one that is unwelcome or unpleasant'.
Some synonyms of the word are: 'variation', 'fluctuation', 'ups & downs' and 'change'.
The collocation of the word is:
the vicissitudes of life
the vicissitude of seasons
the vicissitudes of fortune
Examples:
IELTS Speaking :
He had the ability to change with the times and to share the vicissitudes of opinion.
IELTS Writing:
The professional writer has to undergo a wide range of sad vicissitudes." Speaking :
He had the ability to change with the times and to share the vicissitudes of opinion.
For exercises to learn the usage properly, click on the given link.